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Hypertension: Development of a prediction model to adjust self-reported hypertension prevalence at the community level

机译:高血压:开发预测模型,以调整社区层面自我报告的高血压患病率

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摘要

Abstract Background Accurate estimates of hypertension prevalence are critical for assessment of population health and for planning and implementing prevention and health care programs. While self-reported data is often more economically feasible and readily available compared to clinically measured HBP, these reports may underestimate clinical prevalence to varying degrees. Understanding the accuracy of self-reported data and developing prediction models that correct for underreporting of hypertension in self-reported data can be critical tools in the development of more accurate population level estimates, and in planning population-based interventions to reduce the risk of, or more effectively treat, hypertension. This study examines the accuracy of self-reported survey data in describing prevalence of clinically measured hypertension in two racially and ethnically diverse urban samples, and evaluates a mechanism to correct self-reported data in order to more accurately reflect clinical hypertension prevalence. Methods We analyze data from the Detroit Healthy Environments Partnership (HEP) Survey conducted in 2002 and the National Health and Nutrition Examination (NHANES) 2001–2002 restricted to urban areas and participants 25 years and older. We re-calibrate measures of agreement within the HEP sample drawing upon parameter estimates derived from the NHANES urban sample, and assess the quality of the adjustment proposed within the HEP sample. Results Both self-reported and clinically assessed prevalence of hypertension were higher in the HEP sample (29.7 and 40.1, respectively) compared to the NHANES urban sample (25.7 and 33.8, respectively). In both urban samples, self-reported and clinically assessed prevalence is higher than that reported in the full NHANES sample in the same year (22.9 and 30.4, respectively). Sensitivity, specificity and accuracy between clinical and self-reported hypertension prevalence were ‘moderate to good’ within the HEP sample and ‘good to excellent’ within the NHANES sample. Agreement between clinical and self-reported hypertension prevalence was ‘moderate to good’ within the HEP sample (kappa =0.65; 95% CI = 0.63-0.67), and ‘good to excellent’ within the NHANES sample (kappa = 0.75; 95%CI = 0.73-0.80). Application of a ‘correction’ rule based on prediction models for clinical hypertension using the national sample (NHANES) allowed us to re-calibrate sensitivity and specificity estimates for the HEP sample. The adjusted estimates of hypertension in the HEP sample based on two different correction models, 38.1% and 40.5%, were much closer to the observed hypertension prevalence of 40.1%. Conclusions Application of a simple prediction model derived from national NHANES data to self-reported data from the HEP (Detroit based) sample resulted in estimates that more closely approximated clinically measured hypertension prevalence in this urban community. Similar correction models may be useful in obtaining more accurate estimates of hypertension prevalence in other studies that rely on self-reported hypertension.
机译:摘要背景高血压患病率的准确估算对于评估人群健康以及规划和实施预防和保健计划至关重要。尽管与临床测量的HBP相比,自我报告的数据通常在经济上更可行,而且更容易获得,但这些报告可能在不同程度上低估了临床患病率。理解自我报告数据的准确性并开发可纠正自我报告数据中高血压报告不足的预测模型,可能是开发更准确的人群水平估算值以及规划基于人群的干预措施以降低罹患高血压风险的关键工具,或更有效地治疗高血压。这项研究检查了自我报告的调查数据在描述两个种族和种族不同的城市样本中临床测量的高血压患病率方面的准确性,并评估了一种校正自我报告数据的机制,以便更准确地反映出临床高血压的患病率。方法我们分析了2002年进行的底特律健康环境合作伙伴(HEP)调查和2001-2002年全国健康和营养检查(NHANES)的数据,这些数据仅限于25岁及以上的城市地区和参与者。我们根据NHANES城市样本得出的参数估计值,重新校准HEP样本中的一致性度量,并评估HEP样本中提出的调整的质量。结果与NHANES城市样本(分别为25.7和33.8)相比,HEP样本中的自我报告和临床评估的高血压患病率均较高(分别为29.7和40.1)。在两个城市样本中,自我报告的和临床评估的患病率均高于同年NHANES完整样本中报告的患病率(分别为22.9和30.4)。临床和自我报告的高血压患病率之间的敏感性,特异性和准确性在HEP样本中为“中等至良好”,而在NHANES样本中为“良好至优异”。在HEP样本中,临床和自我报告的高血压患病率之间的一致性为“中等至良好”(kappa = 0.65; 95%CI = 0.63-0.67),而在NHANES样本中其“良好至优秀”(kappa = 0.75; 95%) CI = 0.73-0.80)。应用基于国家样本(NHANES)的临床高血压预测模型的“校正”规则,我们可以重新校准HEP样本的敏感性和特异性估计值。根据两种不同的校正模型(分别为38.1%和40.5%)对HEP样本中的高血压进行调整后的估计值与观察到的40.1%的高血压患病率非常接近。结论将来自国家NHANES数据的简单预测模型应用于来自HEP(基于底特律)样本的自我报告数据,得出的估计值更接近于该城市社区临床测量的高血压患病率。在其他依靠自我报告的高血压的研究中,类似的校正模型可能有助于获得更准确的高血压患病率估计值。

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